We study biological processes related to cancer disparities with a focus on prostate cancer. A primary goal is to uncover the roles of cancer genes and identify new cancer vulnerabilities.

Single-Cell Genomics of Cancer

We use cancer genomics, including single-cell approaches, to understand the mechanisms that drive lethal cancers. Cancer is a disease of the genome, and high-throughput molecular profiling is a powerful tool for both precision medicine and basic research. As part of our efforts, we are involved in the application and development of sequencing technologies such as whole-genome and whole-transcriptome analysis, in particular at a single-cell level. In collaboration with the Shalek Lab at MIT, our lab has implemented the Seq-Well workflow (as described in, through which we prepare tissues for single-cell RNA-sequencing (scRNA-seq). The ability to process samples from various tissues offers an important perspective on the dynamics of cancer development and growth at single-cell resolution. 

Molecular Cancer Disparities

We aim to understand the mechanisms that drive aggressive prostate cancer in African American men and men of African ancestry. We are investigators in the NCI RESPOND study. 

TERT promoter mutations and targeting cellular immortality: Mechanisms of telomerase activation and telomere maintenance

One goal of our research is to understand the mechanisms of telomerase activation in cancer cells based on our discovery of telomerase promoter mutations.  

Molecular Regulators of Cell Proliferation

We also study the role of splicing on molecular regulators of the cell cycle and cancer development.